Ubiquitin carboxyl-terminal hydrolase L5

Ubiquitin carboxyl-terminal hydrolase L5

Rendering based on PDB 3A7S.

Available structures
PDB	3A7S, 3IHR

Identifiers

UCHL5; CGI-70; INO80R; UCH-L5; UCH37

External IDs

OMIM: 610667 MGI: 1914848 HomoloGene: 9326 GeneCards: UCHL5 Gene

Gene Ontology
Molecular function	• ubiquitin thiolesterase activity • ubiquitin-specific protease activity • endopeptidase inhibitor activity • protein binding • peptidase activity • cysteine-type peptidase activity • omega peptidase activity • proteasome binding
Cellular component	• proteasome complex • intracellular • nucleus • cytoplasm • cytosol • Ino80 complex • Ino80 complex
Biological process	• DNA repair • DNA recombination • regulation of transcription, DNA-dependent • ubiquitin-dependent protein catabolic process • negative regulation of endopeptidase activity • protein deubiquitination • lateral ventricle development • midbrain development • forebrain morphogenesis • regulation of proteasomal protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000116750

ENSMUSG00000018189

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
192.98 – 193.03 Mb

Chr 1:
145.62 – 145.65 Mb

PubMed search

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.^[1]^[2]^[3]

References

^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876.
^ Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling". Oncogene 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.
^ "Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51377.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37.". FEBS Lett. 488 (3): 201–5. doi:10.1016/S0014-5793(00)02436-4. PMID 11163772.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389.
Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets.". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146.
Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMC 1589993. PMID 16990800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1589993.
Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMC 1698896. PMID 17139257. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1698896.